![]() Edible fungi grown on plant residues contain proteins, all essential amino acids, unsaturated fatty acids, vitamins, macro and micro elements, polysaccharides, and melanin. The biological value of mushrooms, as a food product containing a unique complex of biologically active substances, has been proved in recent decades. Mushrooms are non-photosynthetic macrofungi with a fleshy distinctive fruiting body which can be either epigenous or hypogenous and visible to the naked eye. Today, the need for novel antimicrobials has become greater than ever in the face of increasing resistance to the older ones, which has led to the exploitation of mushroom as an alternative source of protein both as food and antimicrobials, , ]. Research into natural products has demonstrated significant progress in the discovery of new compounds with antimicrobial activity because nature has generously handed us a source of compounds from medicinal plants, marine and terrestrial organisms, including fungi and bacteria which all has the potential to treat diseases, including infectious diseases. The complexity in treating multi-drug resistant infections has led to an increase in the search for novel and effective antimicrobials, especially structures originating from natural products. This has increased the prevalence and incidence of opportunistic infections significantly beyond hospitalized patients, to the general population. ![]() ![]() In addition, the consequence of acquired mutations assisting bacterial survival has also contributed to the non-susceptibility of microorganisms to commonly used antimicrobials. Today, uncritical use of antibiotics has been the leading cause in the development of drug-resistant bacteria. Despite the impact and benefits of antimicrobial chemotherapy in modern medicine, microbial resistance is now a global threat. The menace has been aggravated by the lack of of new antimicrobials and the persistent emergence and re-emergence of resistant microbial strains in the last few decades. Irrespective of the discovery and wonders of antimicrobial drugs, microbial infection is still a leading cause of morbidity and mortality worldwide.
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